{"id":207,"date":"2019-05-24T16:53:58","date_gmt":"2019-05-24T07:53:58","guid":{"rendered":"http:\/\/dsr-skincare.jp\/column\/?p=207"},"modified":"2022-02-04T13:09:47","modified_gmt":"2022-02-04T04:09:47","slug":"%e7%9a%ae%e8%86%9a%e3%81%ae%e6%a7%8b%e9%80%a0%e3%81%a8%e6%a9%9f%e8%83%bd%e3%80%80%ef%bd%9e%e2%91%a2%e6%84%9f%e8%a6%9a%e6%a9%9f%e8%83%bd%ef%bd%9e","status":"publish","type":"post","link":"https:\/\/dsr-skincare.jp\/column\/?p=207","title":{"rendered":"\u76ae\u819a\u306e\u69cb\u9020\u3068\u6a5f\u80fd\u3000\uff5e\u2462\u611f\u899a\u6a5f\u80fd\uff5e"},"content":{"rendered":"

3.\u3000\u611f\u899a\u3092\u611f\u3058\u308b\u6a5f\u80fd<\/h4>\n

\u611f\u899a\u5668<\/h4>\n

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\u89e6\u899a\u5668\u5b98\uff08\u89e6\u899a\u53d7\u5bb9\u5668\uff09<\/strong><\/p>\n

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\n\u30d1\u30c1\u30cb\u5c0f\u4f53\u306f\u3001\u76ae\u4e0b\u7d44\u7e54\u5185\u3084\u771f\u76ae\u306e\u6df1\u90e8\u306b\u5b58\u5728\u3059\u308b\u5375\u578b\u306e\u5927\u304d\u306a\u611f\u899a\u53d7\u5bb9\u5668\u3067\u3001\u632f\u52d5\u6570\u306e\u9ad8\u3044\u523a\u6fc0\u306b\u5bfe\u3059\u308b\u611f\u5ea6\u304c\u826f\u304f\u3001\u89e6\u308c\u305f\u3068\u304d\u306e\u5fae\u7d30\u306a\u4fe1\u53f7\u3092\u5897\u5e45\u3057\u3066\u3001\u307b\u3093\u306e\u5c0f\u3055\u306a\u632f\u52d5\u3082\u611f\u77e5\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002
\n\u30eb\u30d5\u30a3\u30cb\u7d42\u672b\u306f\u7d21\u9318\u5f62\u3092\u3057\u3066\u3044\u3066\u3001\u771f\u76ae\u306e\u3084\u3084\u6df1\u90e8\u306b\u5b58\u5728\u3057\u3001\u5c40\u6240\u7684\u306a\u5727\u8feb\u3084\u6a2a\u65b9\u5411\u306e\u76ae\u819a\u306e\u5f15\u3063\u5f35\u308a\u306b\u53cd\u5fdc\u3057\u307e\u3059\u3002<\/p>\n

\u6e29\u5ea6\u306e\u611f\u899a<\/strong><\/p>\n

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\n\u81ea\u7531\u795e\u7d4c\u7d42\u672b\u306b\u306f\u3001\u6e29\u5ea6\u611f\u53d7\u6027\u306eTRP\u30c1\u30e3\u30cd\u30eb\u304c\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u3002
\nTRPV1\u306f\u7d0442\u2103\u3067\u6d3b\u6027\u5316\u3055\u308c\u308b\u4fb5\u5bb3\u6027\u71b1\u523a\u6fc0\u53d7\u5bb9\u4f53\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305fTRPM8\u306f\u7d0426\u2103\u4ee5\u4e0b\u3067\u6d3b\u6027\u5316\u3055\u308c\u308b\u51b7\u523a\u6fc0\u53d7\u5bb9\u4f53\u3067\u3059\u3002
\nTRPV1\u306f\u30ab\u30d7\u30b5\u30a4\u30b7\u30f3\u3067\u3082\u6d3b\u6027\u5316\u3055\u308c\u308b\u305f\u3081\u3001\u30c8\u30a6\u30ac\u30e9\u30b7\u3092\u98df\u3079\u308b\u3068\u53e3\u306e\u4e2d\u304c\u71b1\u304f\u611f\u3058\u308b\u306e\u306f\u3053\u306eTRPV1\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u305f\u3081\u3067\u3059\u3002
\n\u307e\u305f\u30e1\u30f3\u30c8\u30fc\u30eb\u306fTRPM8\u3092\u6d3b\u6027\u5316\u3059\u308b\u306e\u3067\u3001\u30e1\u30f3\u30c8\u30fc\u30eb\u3092\u98df\u3079\u308b\u3068\u51b7\u305f\u304f\u51b7\u6dbc\u611f\u304c\u5f97\u3089\u308c\u307e\u3059\u3002
\n\u305d\u306e\u4ed6\u306b\u3082TRPV3\u3084TRPV4\u306f30\uff5e40\u2103\u3042\u305f\u308a\u3067\u6d3b\u6027\u5316\u3059\u308bTRP\u30c1\u30e3\u30cd\u30eb\u3067\u3059\u304c\u3001\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u306b\u591a\u304f\u767a\u73fe\u3057\u3066\u304a\u308a\u3001\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u81ea\u4f53\u3082\u6e29\u5ea6\u3092\u611f\u77e5\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\"\u76ae\u819a\u306e\u611f\u899a\u5668\"<\/p>\n

\u304b\u3086\u307f\u3068\u75db\u307f<\/h4>\n

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\n\u304b\u3086\u307f\u3068\u75db\u307f\u306f\u4e00\u90e8\u306f\u4f1d\u308f\u308b\u795e\u7d4c\u7dda\u7dad\u306e\u7a2e\u985e\u304c\u540c\u3058\u3067\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u57fa\u672c\u7684\u306b\u306f\u7570\u306a\u308b\u7d4c\u8def\u3092\u305f\u3069\u308a\u307e\u3059\u3002
\n\u307e\u305f\u304b\u3086\u307f\u3068\u75db\u307f\u306e\u539f\u56e0\u7269\u8cea\u3082\u7570\u306a\u308a\u307e\u3059\u3002
\n\u304b\u3086\u307f\u3082\u75db\u307f\u3082\u8133\u5185\u306e\u4f3c\u305f\u5834\u6240\u3067\u611f\u77e5\u3057\u307e\u3059\u304c\u3001\u7d30\u304b\u304f\u306f\u7570\u306a\u3063\u305f\u5834\u6240\u3067\u611f\u77e5\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u304b\u3086\u307f\u3092\u611f\u3058\u308b\u5668\u5b98\u30fb\u4f1d\u9054\u7d4c\u8def<\/strong><\/p>\n

\u76ae\u819a\u306e\u611f\u899a\u3092\u8133\u306b\u4f1d\u3048\u308b\u77e5\u899a\u795e\u7d4c\u306b\u306f\u30013\u30bf\u30a4\u30d7\u306e\u795e\u7d4c\u7dda\u7dad\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

    \n
  • A\u03b2\uff1a\u6700\u3082\u592a\u304f\uff08\u76f4\u5f845\uff5e12\u00b5m\uff09\u6709\u9ac4\u795e\u7d4c\u3067\u4f1d\u9054\u304c\u65e9\u3044\u795e\u7d4c\u7dda\u7dad\u3067\u3001\u76ae\u819a\u306e\u89e6\u5727\u611f\u899a\u3092\u4f1d\u3048\u307e\u3059\u3002<\/li>\n
  • A\u03b4\uff1a\u592a\u304f\uff08\u76f4\u5f841\uff5e5\u00b5m\uff09\u6709\u9ac4\u795e\u7d4c\u3067\u4f1d\u9054\u304c\u65e9\u304f\u75db\u307f\u3092\u4f1d\u3048\u307e\u3059\u3002<\/li>\n
  • C\u3000\uff1a\u7d30\u304f\uff08\u76f4\u5f841\u00b5m\u4ee5\u4e0b\uff09\u7121\u9ac4\u795e\u7d4c\u3067\u3001\u4f1d\u9054\u306f\u9045\u304f\u3001\u304b\u3086\u307f\u3084\u920d\u75db\uff08\u6253\u64b2\u3084\u5185\u81d3\u306e\u75db\u307f\u306a\u3069\uff09\u3092\u4f1d\u3048\u307e\u3059\u3002<\/li>\n<\/ul>\n

    C\u7dda\u7dad\u306f\u304b\u3086\u307f\u3082\u75db\u307f\u3082\u4f1d\u3048\u307e\u3059\u304c\u3001\u5171\u901a\u306eC\u7dda\u7dad\u3092\u901a\u308b\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u305d\u308c\u305e\u308c\u5225\u3005\u306e\u7dda\u7dad\u3092\u901a\u3063\u3066\u5225\u3005\u306e\u7d4c\u8def\u3067\u8133\u306b\u4f1d\u308f\u308a\u307e\u3059\u3002<\/p>\n

    \"\u795e\u7d4c\"

    \u6709\u9ac4\u795e\u7d4c\u7dda\u7dad<\/p><\/div>\n

    \u304b\u3086\u307f\u306e\u539f\u56e0\u7269\u8cea<\/strong><\/p>\n

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      \n
    • \u30d2\u30b9\u30bf\u30df\u30f3<\/li>\n
    • \u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\uff12\uff08IL-2)<\/li>\n
    • \u30b5\u30d6\u30b9\u30bf\u30f3\u30b9P<\/li>\n
    • \u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\uff11\u3001\uff18\uff08IL-1, IL-8\uff09<\/li>\n
    • TNF-\u03b1<\/li>\n
    • \u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3(PG)<\/li>\n<\/ul>\n

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      \n\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u5834\u5408\u306f\u3001IgE\u6297\u4f53\u304c\u5927\u91cf\u306b\u4f53\u5185\u3067\u4f5c\u3089\u308c\u3001\u76ae\u819a\u306b\u79fb\u884c\u3057\u3066\u30de\u30b9\u30c8\u7d30\u80de\u306b\u7d50\u5408\u3057\u3001\u3055\u3089\u306b\u30a2\u30ec\u30eb\u30b2\u30f3\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u30de\u30b9\u30c8\u7d30\u80de\u5185\u306e\u30d2\u30b9\u30bf\u30df\u30f3\u306a\u3069\u306e\u5165\u3063\u305f\u9846\u7c92\u3092\u653e\u51fa\u3059\u308b\uff08\u8131\u9846\u7c92\uff09\u3059\u308b\u3053\u3068\u3067\u304b\u3086\u307f\u306a\u3069\u306e\u75c7\u72b6\u304c\u3067\u307e\u3059\u3002<\/p>\n

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      \n\u305d\u306e\u4ed6\u3001\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3\u3084\u30b5\u30d6\u30b9\u30bf\u30f3\u30b9P\u3001\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u306a\u3069\u304c\u3042\u308a\u3001\u30ab\u30d7\u30b5\u30a4\u30b7\u30f3\u3084\u9178\u306a\u3069\u3082\u75db\u307f\u306e\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n

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      \n\u305d\u308c\u306f\u3001\u300c\u304b\u3086\u3044\u300d\u2192\u300c\u63bb\u304f\u300d\u2192\u300c\u63bb\u3044\u305f\u90e8\u5206\u304c\u50b7\u3064\u304f\u300d\u2192\u300c\u50b7\u3064\u3044\u305f\u90e8\u5206\u306b\u708e\u75c7\u304c\u8d77\u3053\u308b\u300d\u2192\u300c\u708e\u75c7\u304c\u60aa\u5316\u3059\u308b\u300d\u2192\u300c\u3082\u3063\u3068\u304b\u3086\u304f\u306a\u308b\u300d\u2192\u300c\u3055\u3089\u306b\u63bb\u304d\u58ca\u3059\u300d\u2192\u300c\u63bb\u3044\u305f\u90e8\u5206\u304c\u3055\u3089\u306b\u50b7\u3064\u304f\u300d\u2192\u30fb\u30fb\u30fb\u3068\u3044\u3046\u60aa\u5faa\u74b0\uff08\u30a4\u30c3\u30c1\u30fb\u30b9\u30af\u30e9\u30c3\u30c1\u30b5\u30a4\u30af\u30eb\u3068\u547c\u3073\u307e\u3059\uff09\u304c\u8d77\u3053\u308b\u305f\u3081\u3067\u3059\u3002
      \n\u63bb\u304f\u3068\u3044\u3046\u884c\u70ba\u306b\u3088\u3063\u3066\u3001\u8868\u76ae\u306e\u7d30\u80de\u304c\u50b7\u3064\u304d\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u3044\u3046\u7269\u8cea\u304c\u5206\u6ccc\u3055\u308c\u307e\u3059\u3002
      \n\u305d\u308c\u306b\u3088\u3063\u3066\u708e\u75c7\u304c\u8d77\u3053\u308a\u3001\u30d2\u30b9\u30bf\u30df\u30f3\u304c\u3070\u3089\u307e\u304b\u308c\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u304b\u3086\u307f\u304c\u5897\u3057\u307e\u3059\u3002
      \n\u307e\u305f\u3053\u306e\u708e\u75c7\u306f\u5468\u8fba\u306b\u3082\u5e83\u304c\u3063\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n

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      \n\u76ae\u819a\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u58ca\u308c\u308b\u3068\u3001\u4e7e\u71e5\u3060\u3051\u3067\u306a\u304f\u3001\u76ae\u819a\u5185\u90e8\u306b\u69d8\u3005\u306a\u523a\u6fc0\u304c\u5165\u308a\u8fbc\u307f\u3001\u305d\u306e\u3088\u3046\u306a\u904e\u654f\u306a\u72b6\u614b\u306b\u306a\u308a\u3001\u304b\u3086\u307f\u3092\u611f\u3058\u3084\u3059\u3044\u72b6\u614b\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n

      \u304b\u3086\u307f\u3092\u3084\u308f\u3089\u3052\u308b<\/strong><\/p>\n

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      \n\u305d\u306e\u305f\u3081\u306b\u75db\u307f\u3092\u4e0e\u3048\u308b\u3053\u3068\u3084\u71b1\u3044\u304a\u6e6f\u3092\u304b\u3051\u308b\u3053\u3068\u306f\u3001\u304b\u3086\u307f\u306e\u4f1d\u9054\u3092\u6291\u5236\u3059\u308b\u305f\u3081
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      \n\u9006\u306b\u51b7\u3084\u3059\u3053\u3068\u306f\u52b9\u679c\u7684\u3067\u3059\u3002
      \n\u51b7\u3084\u3059\u3053\u3068\u306b\u3088\u3063\u3066\u76ae\u819a\u5185\u306e\u9175\u7d20\u53cd\u5fdc\u3092\u9045\u3089\u305b\u3001\u795e\u7d4c\u7d30\u80de\u306e\u304b\u3086\u307f\u306e\u95be\u5024\u3092\u4e0a\u3052\u308b\u50cd\u304d\u3082\u3042\u308a\u307e\u3059\u3002
      \n\u307e\u305fTRPM8\u30ec\u30bb\u30d7\u30bf\u30fc\u3092\u6d3b\u6027\u5316\u3057\u3066\u3001\u304b\u3086\u307f\u306e\u4f1d\u9054\u3092\u6291\u3048\u308b\u3053\u3068\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

      3.\u3000\u611f\u899a\u3092\u611f\u3058\u308b\u6a5f\u80fd \u611f\u899a\u5668 \u76ae\u819a\u306e\u8868\u76ae\u3084\u771f\u76ae\u3001\u76ae\u4e0b\u7d44\u7e54\u306b\u306f\u6e29\u5ea6\u3084\u89e6\u899a\u3001\u75db\u307f\u306a…<\/p>\n","protected":false},"author":1,"featured_media":360,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/dsr-skincare.jp\/column\/index.php?rest_route=\/wp\/v2\/posts\/207"}],"collection":[{"href":"https:\/\/dsr-skincare.jp\/column\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dsr-skincare.jp\/column\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dsr-skincare.jp\/column\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dsr-skincare.jp\/column\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=207"}],"version-history":[{"count":30,"href":"https:\/\/dsr-skincare.jp\/column\/index.php?rest_route=\/wp\/v2\/posts\/207\/revisions"}],"predecessor-version":[{"id":443,"href":"https:\/\/dsr-skincare.jp\/column\/index.php?rest_route=\/wp\/v2\/posts\/207\/revisions\/443"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dsr-skincare.jp\/column\/index.php?rest_route=\/wp\/v2\/media\/360"}],"wp:attachment":[{"href":"https:\/\/dsr-skincare.jp\/column\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=207"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dsr-skincare.jp\/column\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=207"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dsr-skincare.jp\/column\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=207"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}